The accident left her in a coma. Anne's rep told TMZ on Friday the actress is "brain dead," which under California law is considered deceased.
Life support machines are keeping Anne's heart pumping so her organs can be harvested for donations.
A statement from the family reads: "We have lost a bright light, a kind and most joyful soul, a loving mother, and a loyal friend.
Anne will be deeply missed but she lives on through her beautiful sons, her iconic body of work, and her passionate advocacy.
Her bravery for always standing in her truth, spreading her message of love and acceptance, will continue to have a lasting impact.